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This connection has led researchers to focus on better understanding the effect of low vitamin B12 on obesity, insulin resistance, type 2 diabetes, and cardiovascular disease

Initial Loading Dose Protocol For severe deficiency, the first dose is usually 1,000 mcg given intramuscularly

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Intrinsic Factor Inhibiting Conditions Conditions such as autoimmune disease or pernicious anemia cause an inability to make the intrinsic factor that is essential for Vitamin B-12 absorption

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